Phishing emails have gotten much smarter. They can pass normal security checks, come from trusted-looking sources, and read like a real message from a coworker or vendor. In healthcare, even one wrong click can expose sensitive patient information and lead to HIPAA violations.
A 2025 Science Reports study describes hybrid deep learning models that analyze email text using contextual language understanding rather than simple pattern matching. These models combine techniques like BERT, CNNs, GRUs, and attention mechanisms to break messages into pieces, study how the words relate to each other over time, and figure out the sender’s intent.
These AI systems can catch more than 96% of phishing emails, even in tricky datasets where attacks are rare, and they make fewer false alarms. That’s crucial for healthcare, where accidentally blocking a legitimate billing or clinical email can be just as disruptive as letting a phishing attack through.
A PLOS Digital Health study notes, “Epistemic uncertainty can be seen as a lack of information about the best model and can be reduced by adding more training data.” Adding more training data, better features, or more varied samples helps the model learn and makes its predictions more consistent over time. Generative AI can simulate additional email scenarios or create varied training data, helping the model learn patterns it hasn’t encountered before and reducing this type of uncertainty.
Aleatoric uncertainty is different. That uncertainty never fully goes away because it comes from the data itself. Inbound emails are noisy by nature, especially when phishing messages are deliberately written to look legitimate. No amount of extra training can remove the randomness introduced by well-crafted social engineering. Generative AI can help flag ambiguous messages and suggest likely interpretations.
Tools like SpamAssassin or regex-based filters often miss subtle contextual cues, such as phishing emails that are slightly altered to evade detection. In the study ‘A Systematic Review of Cyber Threat Intelligence: The Effectiveness of Technologies, Strategies, and Collaborations in Combating Modern Threats, ’ controlled tests show evasion rates of up to 30% for these methods. These approaches struggle with complex interactions between features and high-dimensional traffic, leading to biases from oversimplified relevance measures.
The limitations include:
In email security, Monte Carlo dropout has become a practical way to spot uncertainty. The idea is that the same email is analyzed multiple times, but each time, small parts of the model are randomly turned off. If the results stay the same, the model is confident. If the results vary, something about the email is unusual.
By measuring how much the predictions fluctuate, using variance, entropy, or mutual information, these methods can flag emails that are tricky or rare phishing attempts. High uncertainty often matches actual mistakes, which is why this approach improves accuracy without just blocking more emails.
Conformal prediction then take it a step further by attaching a confidence range to each prediction, such as guaranteeing that the correct outcome falls within the model’s estimate 80% of the time. Research in medical imaging titled ‘Advancing Phishing Email Detection: A Comparative Study of Deep Learning Models’ uses this approach to explain the vast majority of prediction errors, and the same logic applies to cybersecurity. Emails with low uncertainty can pass through automatically, while high-uncertainty emails are flagged for review without requiring security teams to understand every detail of the model.
Traditional signature-based filters make simple yes/no decisions and often struggle with new or unusual phishing attacks, leading to too many false alarms or missed threats. Generative AI models take a smarter approach.
Processes that measure epistemic uncertainty, previously discussed alongside aleatoric uncertainty, capture randomness from tricky, well-crafted emails. Studies, like one in PLOS Digital Health, show this method works much better than traditional filters in catching high-risk emails like AI-generated phishing that mimics HIPAA notices.
During analysis, the email is broken into tokens and examined using attention-based feature extraction. Generative augmentation creates rare phishing examples during training, helping the model learn what it hasn’t seen before. Instead of rigid rules, it applies adaptive thresholds, like automatically sending emails with high uncertainty to quarantine, making security smarter and more flexible.
See also: HIPAA Compliant Email: The Definitive Guide (2025 Update)
Generative AI refers to machine learning models that create new content, text, images, audio, or code, based on patterns learned from existing data.
Metrics vary by application, including accuracy, F1-score, perplexity (for text), image similarity metrics, or predictive uncertainty measures like Monte Carlo dropout or conformal prediction.
Models can be guided using rules, human feedback, or reinforcement learning, but enforcement is imperfect.